Pharmacologic Substance
ondansetron hydrochloride
[ on-dan-seh-tron hy-droh-klor-ide ]
Effect:
Decreased Central Nervous System Serotonin Activity; Decreased Peripheral Nervous System Serotonin Activity; Emesis Suppression
May Prevent:
Postoperative Nausea and Vomiting
May Treat:
Alcoholism
More Information:
Definitions related to ondansetron hydrochloride:
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The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.NCI ThesaurusU.S. National Cancer Institute, 2021
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