Pharmacologic Substance
oxycodone
ox·y·co·done [ ok-see-koh-dohn ]
Brand Names:
Endocet; Endodan Reformulated May 2009; Nalocet; Oxaydo; Oxycontin; Oxyfast; Percocet; Primlev; Prolate; Roxicodone; Roxybond; Troxyca; Xtampza
Effect:
Analgesia; Decreased GI Motility; Decreased Medullary Respiratory Drive; Decreased Organized Electrical Activity; Increased Histamine Production
May Treat:
Pain, Postoperative
More Information:
Definitions related to oxycodone:
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A semisynthetic derivative of CODEINE.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability.NCI ThesaurusU.S. National Cancer Institute, 2021
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Oxycodone, semisynthetic drug with potent pain-relieving effects that is derived from thebaine, an alkaloid that occurs naturally in the opium poppy (Papaver somniferum). Oxycodone was synthesized from thebaine in 1916 and was first used clinically the following year. Today it is prescribed for...Encyclopedia Britannica, Inc., 2020
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