Pharmacologic Substance
paclitaxel
[ pa-klih-tak-sil ]
Brand Names:
Abraxane
Effect:
Decreased Mitosis
May Treat:
Breast Neoplasms;
Carcinoma, Non-Small-Cell Lung;
Ovarian Neoplasms;
Sarcoma, Kaposi
More Information:
Definitions related to paclitaxel:
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A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A drug used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi sarcoma. It is also used together with another drug to treat non-small cell lung cancer. Paclitaxel is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Extract from the Pacific yew tree Taxus brevifolia which stabilizes microtubles and is therefore used as a cytologic probe for microtubule function, and clinically as an antineoplastic; do not confuse with a bile salt laxative with the trade name Taxol.CRISP ThesaurusNational Institutes of Health, 2006
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(paclitaxel preparation) Any formulation containing paclitaxel, an antimitotic taxane.NCI ThesaurusU.S. National Cancer Institute, 2021
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