Pharmacologic Substance
pargyline
Definitions related to pargyline:
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A monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect.NCI ThesaurusU.S. National Cancer Institute, 2021
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A monoamine oxidase inhibitor with antihypertensive properties.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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