Pharmacologic Substance
paroxetine hydrochloride
[ puh-rok-suh-teen hy-droh-klor-ide ]
Effect:
Increased Brain Stem Serotonin Activity
May Treat:
Depressive Disorder;
Feeding and Eating Disorders;
Obsessive-Compulsive Disorder;
Panic Disorder;
Phobic Disorders;
Stress Disorders, Post-Traumatic
More Information:
Definitions related to paroxetine hydrochloride:
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A drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness.NCI ThesaurusU.S. National Cancer Institute, 2021
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