Pharmacologic Substance
pazopanib
Brand Names:
Votrient
Effect:
Decreased Endothelial Proliferation; Vascular Growth Decrease
May Treat:
Carcinoma, Renal Cell;
Soft Tissue Neoplasms
More Information:
Definitions related to pazopanib:
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A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.NCI ThesaurusU.S. National Cancer Institute, 2021
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