Pharmacologic Substance
pemetrexed disodium
[ peh-meh-trek-sed dy-soh-dee-um ]
Effect:
Decreased DNA Integrity; Decreased Protein Synthesis
May Treat:
Carcinoma, Non-Small-Cell Lung;
Neoplasms, Mesothelial
Definitions related to pemetrexed disodium:
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A drug used alone or with another drug to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma. It is being studied in the treatment of other types of cancer. Pemetrexed disodium blocks DNA synthesis and may kill cancer cells. It is a type of folate antagonist.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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