Pharmacologic Substance
pemoline
[ pem-uh-leen, -lin ]
Effect:
Increased Cerebral Cortex Dopamine Activity; Increased Cerebral Cortex Organized Electrical Activity; Increased Medullary Respiratory Drive
May Treat:
Attention Deficit Disorder with Hyperactivity;
Narcolepsy
Definitions related to pemoline:
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A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An oxazolidine compound with central nervous system (CNS) stimulant property. Although pemoline has pharmacological activity similar to other CNS stimulants, the exact mechanism and site of action are unknown. This agent has minimal sympathomimetic properties, but animal studies indicate it may work through dopaminergic mechanisms. Pemoline has been withdrawn from the U.S. market because of the agent's association with life threatening hepatic failure.NCI ThesaurusU.S. National Cancer Institute, 2021
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