Pharmacologic Substance
trimethadione
[ trahy-meth-uh-dahy-ohn ]
Effect:
Neurotransmitter & Neuromuscular Transmitter Activity Alteration
May Treat:
Epilepsy, Absence
Definitions related to trimethadione:
  • A dione-type anticonvulsant with antiepileptic activity. Trimethadione reduces T-type calcium currents in thalamic neurons, thereby stabilizing neuronal membranes, raising the threshold for repetitive activities in the thalamus and inhibiting corticothalamic transmission. This decreases the abnormal thalamocortical rhythmicity, which is thought to underlie the paroxysmal three-cycle-per-second spike-and-wave pattern seen with absence (petit mal) seizures.
    NCI
    U.S. National Cancer Institute, 2021
  • An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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