Pharmacologic Substance
penicillamine
[ pen-uh-sil-uh-meen, -min ]
Brand Names:
Cuprimine; Depen; D-Penamine
Effect:
Decreased Immunologically Active Molecule Activity
May Treat:
Arthritis, Rheumatoid;
Cystinuria;
Hepatolenticular Degeneration;
Lead Poisoning;
Liver Cirrhosis, Biliary;
Mercury Poisoning
More Information:
Definitions related to penicillamine:
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3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Beta dimethyl analog of cysteine; USP lists as a chelating agent.CRISP ThesaurusNational Institutes of Health, 2006
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