Pharmacologic Substance
tiopronin
Brand Names:
Thiola
Effect:
Increased Organic Ion Degradation
May Prevent:
Kidney Calculi
More Information:
Definitions related to tiopronin:
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An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.NCI ThesaurusU.S. National Cancer Institute, 2021
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Sulfhydryl acylated derivative of GLYCINE.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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