Pharmacologic Substance
tiopronin
Brand Names:
Thiola
Effect:
Increased Organic Ion Degradation
May Prevent:
Kidney Calculi
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to tiopronin:
  • An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.
    NCI
    U.S. National Cancer Institute, 2021
  • Sulfhydryl acylated derivative of GLYCINE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.