Pharmacologic Substance
pentamidine isethionate Audio
[ pen-ta-mih-deen i-seh-thy-oh-nayt ]
Effect:
Decreased DNA Replication; Decreased Protein Synthesis; Decreased RNA Replication; DNA Integrity Alteration; Lipid Metabolism Alteration; RNA Integrity Alteration
May Prevent:
Pneumonia, Pneumocystis
May Treat:
Leishmaniasis, Visceral; Pneumonia, Pneumocystis; Trypanosomiasis
More Information:
ChemID; DailyMed; PDR
Definitions related to pentamidine isethionate:
  • A drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent that appears to interact with the minor groove of AT-rich DNA regions of the pathogen genome, interfering with DNA replication and function. It is effective in the treatment of trypanosomiasis, leishmaniasis, some fungal infections, and Pneumocystis carinii pneumonia in HIV-infected patients. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.