Pharmacologic Substance
phenoxybenzamine
[ fi-nok-see-ben-zuh-meen ]
Brand Names:
Dibenzyline
Effect:
Decreased Bladder Sphincter Tone; Decreased Blood Pressure; Decreased Urethra Smooth Muscle Tone
May Treat:
Hypertension, Malignant; Pheochromocytoma; Urinary Bladder Neck Obstruction; Urinary Incontinence
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to phenoxybenzamine:
  • A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
    NCI
    U.S. National Cancer Institute, 2021
  • An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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