Pharmacologic Substance
phenoxybenzamine
[ fi-nok-see-ben-zuh-meen ]
Brand Names:
Dibenzyline
Effect:
Decreased Bladder Sphincter Tone; Decreased Blood Pressure; Decreased Urethra Smooth Muscle Tone
May Treat:
Hypertension, Malignant;
Pheochromocytoma;
Urinary Bladder Neck Obstruction;
Urinary Incontinence
More Information:
Definitions related to phenoxybenzamine:
-
A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.NCI ThesaurusU.S. National Cancer Institute, 2021
-
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
Return to OpenMD Medical Dictionary
> P
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.