Pharmacologic Substance
diethylpropion
[ dahy-eth-uhl-proh-pee-uhn ]
Brand Names:
Tenuate
Effect:
Increased Cerebral Cortex Dopamine Activity; Increased Cerebral Cortex Norepinephrine Activity; Increased Sympathetic Activity
May Treat:
Obesity
More Information:
Definitions related to diethylpropion:
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A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An amphetamine derivative and a sympathomimetic stimulant with anti-obesity and appetite-suppressant properties. Diethylpropion stimulates neurons to release and maintain high levels of catecholamines including dopamine and norepinephrine resulting in a suppression of hunger signals and appetite. This agent may also indirectly affect leptin-neuropeptide Y (NPY) neurotransmission, which exerts control on metabolic processes such as food intake and body weight homeostasis. Via elevated catecholamine, diethylpropion indirectly elevates leptin levels in the brain, which in turn inhibits production of NPY, a potent stimulator of feeding behavior, thereby preventing the initiation of eating, increasing energy expenditure, and decreasing fat storage.NCI ThesaurusU.S. National Cancer Institute, 2021
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