Pharmacologic Substance
phenprocoumon
Effect:
Decreased Coagulation Factor Activity; Decreased Coagulation Factor Concentration
May Prevent:
Pulmonary Embolism; Thromboembolism; Venous Thrombosis
May Treat:
Pulmonary Embolism;
Thromboembolism;
Venous Thrombosis
Definitions related to phenprocoumon:
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An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation.NCI ThesaurusU.S. National Cancer Institute, 2021
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Coumarin derivative that acts as a long acting oral anticoagulant.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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