Pharmacologic Substance
dicumarol
[ dahy-koo-muh-rawl, -rol, -kyoo- ]
Effect:
Decreased Coagulation Factor Activity; Decreased Coagulation Factor Concentration
May Prevent:
Pulmonary Embolism; Thromboembolism; Venous Thrombosis
May Treat:
Pulmonary Embolism;
Thromboembolism;
Venous Thrombosis
Definitions related to dicumarol:
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A hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicumarol is a competitive inhibitor of vitamin K epoxide reductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.NCI ThesaurusU.S. National Cancer Institute, 2021
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An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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