Antibiotic
pibrozelesin
Definitions related to pibrozelesin:
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A semisynthetic anticancer drug that is a type of antitumor antibiotic.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.NCI ThesaurusU.S. National Cancer Institute, 2021
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