Pharmacologic Substance
pomalidomide
[ pah-muh-lih-doh-mide ]
Brand Names:
Pomalyst
Effect:
Cellular Growth Phase Reduction; Cellular Proliferation Alteration; Increased Cellular Death; Vascular Growth Decrease
May Treat:
Multiple Myeloma
More Information:
Definitions related to pomalidomide:
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A substance being studied in the treatment of prostate cancer, multiple myeloma, and other types of cancer. Pomalidomide is a form of the drug thalidomide. It stops the growth of blood vessels, stimulates the immune system, and may kill cancer cells. Pomalidomide is a type of angiogenesis inhibitor and a type of immunomodulatory agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.NCI ThesaurusU.S. National Cancer Institute, 2021
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