Pharmacologic Substance
primaquine
pri·ma·quine [ prahy-muh-kween ]
Effect:
Decreased DNA Integrity; Decreased Protein Synthesis
May Prevent:
Malaria, Vivax
May Treat:
Malaria, Falciparum;
Malaria, Vivax
More Information:
Definitions related to primaquine:
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A synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts). (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Aminoquinolone compound used as an antimalarial against the extraerythrocytic forms of Plasmodium vivax and P ovale and the gametocytes of P falciparum.CRISP ThesaurusNational Institutes of Health, 2006
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An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Primaquine, synthetic drug used in the treatment of malaria, an infection caused by the protozoan parasite Plasmodium transmitted to humans by the bite of various species of Anopheles mosquitoes. Introduced into medicine in the 1950s, primaquine is one of an important series of chemically related...Encyclopedia Britannica, Inc., 2020
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