Pharmacologic Substance
chloroquine

chlo·ro·quine [ klawr-uh-kwin, -kween, klohr- ]
Effect:
Decreased Metabolic Rate; Decreased Prostaglandin Activity; Nucleic Acid Replication Alteration
May Prevent:
Malaria
May Treat:
Amebiasis;
Arthritis, Rheumatoid;
Lupus Erythematosus, Discoid;
Malaria, Avian;
Malaria, Falciparum;
Pemphigus;
Scleroderma, Systemic
More Information:
Definitions related to chloroquine:
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A 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. This agent may also interfere with the biosynthesis of nucleic acids. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation.NCI ThesaurusU.S. National Cancer Institute, 2021
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Antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus.CRISP ThesaurusNational Institutes of Health, 2006
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The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Chloroquine, synthetic drug used in the treatment of malaria. Chloroquine, discovered in 1934 and introduced into medicine in the 1940s, is a member of an important series of chemically related antimalarial agents, the quinoline derivatives. Chloroquine is administered orally as chloroquine...Encyclopedia Britannica, Inc., 2020
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