Pharmacologic Substance
procarbazine
Brand Names:
Matulane
Effect:
Decreased DNA Replication; Decreased Mitosis; Decreased Protein Synthesis; Decreased RNA Replication
May Treat:
Brain Neoplasms;
Hodgkin Disease;
Lung Neoplasms;
Lymphoma, Non-Hodgkin;
Melanoma;
Multiple Myeloma
More Information:
Definitions related to procarbazine:
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A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.NCI ThesaurusU.S. National Cancer Institute, 2021
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An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Antineoplastic agent specific for the S phase of the cell cycle, used in combination with mechlorethamine, vincristine, and prednisone (MOPP protocol) in the treatment of Hodgkin's disease, and in treatment of other neoplasms.CRISP ThesaurusNational Institutes of Health, 2006
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The active ingredient in a drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Procarbazine blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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