Pharmacologic Substance
propylthiouracil
[ proh-pil-thahy-oh-yoor-uh-sil ]
Effect:
Decreased Iodine Organification; Decreased Protein Modification; Decreased Protein Synthesis; Decreased Thyroid Hormone Iodination
May Treat:
Goiter;
Thyroid Crisis
More Information:
Definitions related to propylthiouracil:
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A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A thiourea derivative with antithyroid property. Propylthiouracil (PTU) interferes with the oxidation of iodine possibly by interaction with peroxidase or a peroxidase-mediated complex reaction, thereby inhibiting synthesis of thyroid hormones tri-iodothyronine (T3) and thyroxine (T4). In addition, this agent inhibits the Type I 5'-deiodinase (D1), an enzyme involved in the peripheral conversion of thyroxine to tri-iodothyronine. This results in decreased plasma triodothyronine concentrations and decreased entrance of thyroxine into cells thereby reducing thyroid hormone activity.NCI ThesaurusU.S. National Cancer Institute, 2021
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