Pharmacologic Substance
quinapril
Brand Names:
Accupril; Accuretic
Effect:
Decreased Blood Pressure; Decreased Bradykinin Degradation; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Prevent:
Diabetic Nephropathies; Hypertrophy, Left Ventricular; Ventricular Dysfunction, Left
May Treat:
Diabetic Nephropathies;
Heart Failure;
Hypertension;
Ventricular Dysfunction, Left
More Information:
Definitions related to quinapril:
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A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.NCI ThesaurusU.S. National Cancer Institute, 2021
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A tetrahydroisoquinoline derivative and ANGIOTENSIN CONVERTING ENZYME inhibitor that is used in the treatment of HYPERTENSION and HEART FAILURE.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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