Pharmacologic Substance
ramipril
Brand Names:
Altace
Effect:
Decreased Blood Pressure; Decreased Bradykinin Degradation; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Prevent:
Diabetic Nephropathies; Hypertrophy, Left Ventricular; Ventricular Dysfunction, Left
May Treat:
Diabetic Nephropathies;
Heart Failure;
Hypertension;
Ventricular Dysfunction, Left
More Information:
Definitions related to ramipril:
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A long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.NCI ThesaurusU.S. National Cancer Institute, 2021
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