Enzyme
ranpirnase Audio
[ ran-per-nays ]
Definitions related to ranpirnase:
  • (onconase) A substance being studied in the treatment of cancer. It is a type of ribonuclease enzyme.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A natural homologue of ribonuclease A isolated from the eggs of the frog Rana pipiens. Ranpirnase primarily degrades cellular transfer RNA with a substrate specificity for uridine-guanidine base-pair sequences, resulting in inhibition of protein synthesis and cytotoxicity. This agent also activates caspase-9 in mitochondria, resulting in tumor cell apoptosis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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