Functional Concept
rectal route
Subclass of:
Administration, Mucosal
Definitions related to rectal route of drug administration:
  • (rectal) Administration to the rectum. (FDA)
    CDISC Terminology
    Clinical Data Interchange Standards Consortium (CDISC), 2021
  • (administration, rectal) The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (rectal route of administration) The introduction of a substance into the gastrointestinal tract by the way of the rectum, usually for systemic action. Depending on the molecular structure, drugs cross the rectal wall via either intercellular or tight junctions interconnecting the mucosal cells. Drug absorption is usually around 50% of normal oral dose. Due to the drainage pattern of the rectal veins, the hepatic first-pass effect tends to increase as the dosage form is placed deeper into the rectum. Solid suppositories represent greater than 98% of all rectal dosage forms.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • (medication administration: rectal) Preparing and inserting rectal suppositories
    Nursing Interventions Classification
    University of Iowa, 2007
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