Genetic Function
replication initiation
rep·li·ca·tion in·i·ti·a·tion
Definitions related to replication initiation:
  • DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. (from MedLine 11395402)
    NCI
    U.S. National Cancer Institute, 2021
  • (dna replication initiation) The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
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