Biologically Active Substance
retinoblastoma protein
ret·ino·blas·to·ma pro·tein [ ret-noh-bla-stoh-muh proh-teen, -tee-in ]
Subclass of:
Tumor Suppressor Proteins; DNA-Binding Proteins; Nuclear Proteins; Phosphoproteins
Definitions related to retinoblastoma protein:
  • Nuclear protein product of the Rb gene; regulated by phosphorylation; inhibits cell cycle progression in its dephosphorylated form.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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