Biologically Active Substance
rgs proteins
Subclass of:
GTPase-Activating Proteins
Definitions related to rgs proteins:
  • A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • (rgs family protein) RGS family proteins activate GTPase and regulate G protein signaling by stimulating the inactivation of heterotrimeric G proteins. RGS family proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. There are indications that a subset of RGS proteins regulate specific G protein-coupled receptor pathways.
    NCI
    U.S. National Cancer Institute, 2021
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