Antibiotic
romidepsin Audio
[ roh-mih-dep-sin ]
Brand Names:
Istodax
Effect:
Increased Cellular Death
May Treat:
Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to romidepsin:
  • A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins.
    NCI
    U.S. National Cancer Institute, 2021
  • A substance being studied in the treatment of cancer. Romidepsin is a type of depsipeptide and histone deacetylase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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