Pharmacologic Substance
rubitecan
Definitions related to rubitecan:
  • A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • (nitrocamptothecin) An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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