Disease or Syndrome
sinus histiocytosis
Subclass of:
Histiocytosis, Non-Langerhans-Cell
Definitions related to sinus histiocytosis:
  • A morphologic finding indicating the presence of histiocytic infiltrates within distended lymph node sinuses.
    NCI
    U.S. National Cancer Institute, 2021
  • Rosai-Dorfman disease is a rare disorder characterized by accumulation of histiocytes and massive lymphadenopathy, particularly in the neck and head. Rosai-Dorfman disease is most common among patients 20 years, particularly blacks. The cause is unknown.
    Merck Manuals
    Merck & Co., Inc., 2025
  • Rosai-Dorfman disease was first described by Rosai and Dorfman in 1969. It is a benign disease which is characterized by over-production and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body, most often those of the neck (cervical). Other lymph node groups may also be involved and, in some...
    NIH Genetic and Rare Diseases
    National Center for Advancing Translational Sciences
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