Antibiotic
sirolimus
[ sih-roh-lih-mus ]
Brand Names:
Rapamune
Effect:
Cellular Growth Phase Arrest; Cellular Synthetic Phase Arrest; Decreased T Lymphocyte Production
May Prevent:
Graft vs Host Disease
More Information:
Definitions related to sirolimus:
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A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Novel immunosuppressive drug used in transplantation; may inhibit receptor mediated activation of mast cells.CRISP ThesaurusNational Institutes of Health, 2006
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Rapamycin, drug characterized primarily by its ability to suppress the immune system, which led to its use in the prevention of transplant rejection. Rapamycin is produced by the soil bacterium Streptomyces hygroscopicus. The drug's name comes from Rapa Nui, the indigenous name of Easter Island...Encyclopedia Britannica, Inc., 2020
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