Pharmacologic Substance
maytansine
Subclass of:
Lactams, Macrocyclic; Macrolides
Definitions related to maytansine:
  • An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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