Pharmacologic Substance
sulfamethizole
Effect:
Decreased Folic Acid Modification
May Treat:
Gram-Negative Bacterial Infections;
Gram-Positive Bacterial Infections;
Urinary Tract Infections
More Information:
Definitions related to sulfamethizole:
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A broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfamethizole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.NCI ThesaurusU.S. National Cancer Institute, 2021
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A sulfathiazole antibacterial agent.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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