Biologically Active Substance
survivin
Subclass of:
Microtubule-Associated Proteins;
inhibitor-of-apoptosis protein;
Cell Cycle Proteins
Definitions related to survivin:
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An anti-apoptosis protein expressed in lymphoma and cancers of lung, colon, pancreas, prostate and breast; potent inhibitor of some caspases.CRISP ThesaurusNational Institutes of Health, 2006
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An apoptosis inhibitory protein that contains a single baculoviral IAP repeat (BIR) domain. It associates with MICROTUBULES and functions to regulate cell proliferation as a component of the chromosome passage protein complex (CPC), performing essential roles for localization of the complex, chromosome alignment, segregation during MITOSIS and CYTOKINESIS, and assembly of the MITOTIC SPINDLE. It is expressed by fetal kidney and liver cells and highly expressed in ADENOCARCINOMA and high-grade LYMPHOMA.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(survivin antigen) A tumor-associated antigen. Vaccination with survivin antigen may result in a cytotoxic T-cell response against survivin antigen-expressing tumor cells, resulting in decreased tumor cell proliferation and tumor cell death. Overexpressed in many tumors, endogenous survivin inhibits tumor cell apoptosis.NCI ThesaurusU.S. National Cancer Institute, 2021
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