Enzyme
tenecteplase
Brand Names:
Tnkase
Effect:
Increased Thrombolysis
May Treat:
Coronary Thrombosis;
Myocardial Infarction
More Information:
Definitions related to tenecteplase:
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A 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction.NCI ThesaurusU.S. National Cancer Institute, 2021
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A tissue plasminogen activator enzyme that acts as a fibrinolytic agent; it is used for the dissolution of blood clots, such as those that occur in acute MYOCARDIAL INFARCTION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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