Pharmacologic Substance
tetanus toxin
More Information:
ChemID; DailyMed; DrugInfo; PDR
Definitions related to tetanus toxin:
  • Potent exotoxin produced by Clostridium tetani, consisting of two components, one a neurotoxin (tetanospasmin) and the other a hemolysin (tetanolysin); causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal convulsions.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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