Pharmacologic Substance
thioinosine
Subclass of:
Thionucleosides; Inosine
Definitions related to thioinosine:
  • A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de novo purine synthesis and perturbs the pool of nucleotides necessary for DNA replication. As a result, this agent inhibits DNA synthesis, blocks cellular proliferation and induces apoptosis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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