Pharmacologic Substance
thiothixene
[ thahy-oh-thik-seen ]
Effect:
Decreased Dopamine Activity; Decreased Norepinephrine Activity
May Treat:
Psychotic Disorders;
Schizophrenia
More Information:
Definitions related to thiothixene:
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A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors.NCI ThesaurusU.S. National Cancer Institute, 2021
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A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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