Pharmacologic Substance
tirofiban
Brand Names:
Aggrastat
Effect:
Decreased Platelet Aggregation
May Prevent:
Myocardial Ischemia; Reperfusion Injury; Stroke; Thromboembolism
May Treat:
Angina, Unstable;
Coronary Disease;
Myocardial Infarction
More Information:
Definitions related to tirofiban:
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A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time.NCI ThesaurusU.S. National Cancer Institute, 2021
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Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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