Antibiotic
tobramycin
to·bra·my·cin [ toh-bruh-mahy-sin ]
Brand Names:
Bethkis; Kitabis; Tobi; Tobradex; Tobrex; Zylet
Effect:
Cell Membrane Alteration; Decreased Protein Synthesis
May Treat:
Bone Diseases, Infectious;
Central Nervous System Infections;
Eye Infections, Bacterial;
Intraabdominal Infections;
Pseudomonas Infections;
Respiratory Tract Infections;
Sepsis;
Skin Diseases, Infectious;
Staphylococcal Infections;
Urinary Tract Infections
More Information:
Definitions related to tobramycin:
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An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.NCI ThesaurusU.S. National Cancer Institute, 2021
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An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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