Vitamin
tocotrienols
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Definitions related to tocotrienols:
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Any of the four forms, alpha, beta, gamma and delta, of a member of the vitamin E family, with potential hypocholesterolemic, antithrombotic, antioxidant, immunomodulating and antineoplastic activities. Tocotrienol inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, thereby lowering cholesterol levels. In addition, tocotrienol acts through multiple signal transduction pathways to induce cell cycle arrest and caspase-mediated apoptosis, and to decrease tumor cell proliferation. In addition, this agent may inhibit angiogenesis through the blockage of vascular endothelial growth factor receptor (VEGFR) and the subsequent inhibition of tumor cell-induced vessel formation. Also, this agent prevents free radical formation and inhibits lipid peroxidation, thereby preventing DNA cell damage. Tocotrienol farnesyl isoprenoid side chains contain 3 double bonds, which are absent in tocopherols, likely contribute to its anti-cancer activities.NCI ThesaurusU.S. National Cancer Institute, 2021
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Class of compounds having one to three methyl groups on a chromanol ring with a long unsaturated 12-carbon side chain with three methyl groups along the chain and two methyl groups at the end; may contribute to vitamin E activity.CRCH Nutrition TerminologyCancer Research Center of Hawaii, University of Hawaii, 2021
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Natural analogs of TOCOPHEROLS exhibiting antioxidant activity. These tocol derivatives and isomers contain a benzopyran ring and an unsaturated isoprenoid side chain.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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