Pharmacologic Substance
topiramate
Brand Names:
Qsymia; Qudexy; Topamax; Trokendi
Effect:
Decreased Glutamate Activity; Increased GABA Activity
May Prevent:
Migraine Disorders
May Treat:
Bipolar Disorder;
Epilepsies, Partial;
Epilepsy, Tonic-Clonic;
Lennox Gastaut Syndrome;
Pain;
Spasms, Infantile
More Information:
Definitions related to topiramate:
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A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.NCI ThesaurusU.S. National Cancer Institute, 2021
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