Pharmacologic Substance
topoisomerase inhibitors
Subclass of:
Antineoplastic Agents; Enzyme Inhibitors
Definitions related to topoisomerase inhibitors:
  • A substance that blocks topoisomerases (enzymes that break and rejoin DNA strands and are needed for cells to divide and grow). Blocking these enzymes may kill cancer cells. Certain topoisomerase inhibitors are being studied in the treatment of cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Any substance that inhibits topoisomerase, an enzyme that cleaves the DNA backbone to relieve torsional stress in a DNA molecule generated during replication, transcription, and other structural transformations. Inhibition of topoisomerase causes DNA damage, inhibition of DNA replication, and apoptosis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Compounds that inhibit the activity of DNA TOPOISOMERASES.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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