Pharmacologic Substance
topotecan
Brand Names:
Hycamtin
Effect:
Decreased DNA Replication
May Treat:
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Small Cell;
Ovarian Neoplasms;
Small Cell Lung Carcinoma;
Uterine Cervical Neoplasms
More Information:
Definitions related to topotecan:
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A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan is a type of topoisomerase inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.NCI ThesaurusU.S. National Cancer Institute, 2021
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An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Antineoplastic drug which acts as a DNA topoisomerase inhibitor.CRISP ThesaurusNational Institutes of Health, 2006
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