Pharmacologic Substance
topotecan hydrochloride
[ toh-poh-tee-kan hy-droh-klor-ide ]
Effect:
Decreased DNA Replication
May Treat:
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Small Cell;
Ovarian Neoplasms;
Small Cell Lung Carcinoma;
Uterine Cervical Neoplasms
More Information:
Definitions related to topotecan hydrochloride:
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A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Hycamtin is a type of topoisomerase inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.NCI ThesaurusU.S. National Cancer Institute, 2021
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