Gene or Genome
trb gene
Subclass of:
Genes, T-Cell Receptor
Definitions related to trb gene:
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(t-cell receptor beta locus) This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (from LocusLink)NCI ThesaurusU.S. National Cancer Institute, 2021
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(genes, t-cell receptor beta) DNA sequences encoding the beta chain of the T-cell receptor. The genomic organization of the TcR beta genes is essentially the same in all species and is similar to the organization of Ig genes.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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