Pharmacologic Substance
troglitazone
Effect:
Decreased Gluconeogenesis; Increased Glucose Transport into Cells; Increased Glycolysis
May Treat:
Diabetes Mellitus, Type 2
Definitions related to troglitazone:
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A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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