Gene or Genome
tumor suppressor gene Audio
[ too-mer suh-preh-ser jeen ]
Subclass of:
Genes, Recessive; Genes, Neoplasm
Definitions related to tumor suppressor genes:
  • A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA) in antioncogenes may lead to cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Genes whose loss or deactivation leads to neoplastic transformation; compare with ONCOGENE and PROTOONCOGENE.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Tumor Suppressor Genes encode proteins whose functions inhibit expression of tumorigenic phenotypes by holding cellular proliferation in check. When inactivated or lost, a barrier to normal proliferation is removed and deregulated growth is possible. (NCI)
    NCI
    U.S. National Cancer Institute, 2021
  • (genes, tumor suppressor) Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Tumour suppressor gene, any of a class of genes that are normally involved in regulating cell growth but that may become cancer-causing when damaged. Tumour suppressor genes encode for proteins that are involved in inhibiting the proliferation of cells, which is crucial to normal cell development...
    Encyclopedia Britannica
    Encyclopedia Britannica, Inc., 2025
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